![]() ![]() The possible effects of these subtle elevations of P are controversial. Elevated P levels on the day of trigger have been reported with a markedly varied incidence (5% to 30%) 1, 2 due to divergences in the definition, population characteristics and/or treatment protocols. ![]() Subtle increases in serum progesterone (P) levels at the end of the follicular phase in controlled ovarian stimulation (COS) cycles are a frequent phenomenon in in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment cycles despite the use of gonadotropin-releasing hormone (GnRH) agonists and antagonists 1. We concluded that elevated P on the trigger day had no negative effect on the final outcome of the hMG + MPA treatment cycles based on FET. However, there were no significant differences in the oocyte retrieval rates, fertilization rates, implantation rates, clinical pregnancy rates and live birth rates between the groups based on frozen embryo transfer (FET). The mean stimulation duration, total hMG dose, serum follicle stimulating hormone (FSH), estrogen(E2) on the trigger day and the number of oocytes in patients with elevated P were significantly higher than patients with P < 1 ng/mL (P < 0.05). The primary outcome measure was live birth rate. The cycles were grouped according to the P level on the trigger day: <1 ng/mL, between 1–1.5 ng/ml (including 1), between 1.5–2 ng/mL (including 1.5) and ≥2 ng/mL. To demonstrate the incidence and effects of elevated progesterone (P) on the trigger day on the outcome of in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles using Medroxyprogesterone acetate (MPA) co-treated with Human Menotrophins Gonadotrophin (hMG + MPA), we performed a retrospective analysis including 4106 IVF/ICSI cycles. ![]()
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